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Impact of Fabry Disease on the Heart & Kidneys

This video explains how Fabry disease affects the heart and kidneys. Heart disease and kidney failure are both major causes of premature death in patients with Fabry disease. Accumulation of globotriaosylceramide (Gb3) in heart tissues leads to structural and functional changes in the heart while Gb3 storage in the kidney leads to progressive worsening of kidney function and end-stage kidney disease. This video demonstrates how heart and kidney disease affect each other and why an understanding of this complex interplay is central to improving patient outcomes.

Fabry Disease