There are already more than 50 nanomedicine formulations in the market and over 400 currently in clinical trials, thanks to the unique versatility of these therapeutics compared to conventional drugs. Several European projects are developing nanomedicines in areas with unmet medical needs, such as Cupido (cardiovascular disease), B-Smart (neurodegenerative disorders), Smart-4-Fabry (Fabry disease) and New Deal (inflammatory bowel disease).