Smart4fabry / Communication  / Newsletter #5

Newsletter #5

A large variety of nanoparticle-based delivery systems have become increasingly important for therapeutic applications. A critical issue lies in the challenge of scaling-up the synthesis and formulation of the nanomaterial from the lab to pilot and then to the industrial scale, while maintaining control over their quality attributes, such as particle mean size . The DELOS Platform is a robust procedure to overcome these challenges, delivering consistent, high quality, therapeutic nanoformulations. In the frame of Smart-4-Fabry, the DELOS procedure has been successfully scaled-up to the pilot plant and consistent, high-quality nanoliposomes loaded with GLA enzyme have been delivered for preclinical GLP toxicology assays.


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